C7 Protein

For Research Use Only. Not for use in diagnostic procedures.

Purified human complement component C7. Complement component C7 is unique to the terminal complement pathway. It is a single chain protein with a molecular weight of 110 kD and is present in plasma at approximately 55 mg/L. Together with the other proteins of the terminal pathway, C7 forms the membrane attack complex or MAC.

All Quidel complement components are tested for functional activity in a standard lytic or applicable functional assay and for biochemical purity by SDS-polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.

Quidel's purified human complement components are useful in a wide variety of immunochemical and research applications. For assistance with a specific protocol, please contact Quidel Technical Support.

References

Nicholson-Weller, Butko, P, Wessels, M. Role of Complement Component C1q in IgG independent Opsonophagocytosis of Group B Streptococus, J. Immunol 163:2761-2768, 1999.

Barbashov, C., Wang C., Nicholson-Weller, A. Serum amyloid P component forms a stable complex with human C5b-6, J. Immunol. 158:3830-3835, 1997.

Koski, C., Dashell, S. Sublytic terminal complement complex decreases Po gene expression in schwan cells, J Neurochem 73(6):2321-2330, 1999.

Liu,C., et al. Interaction between the terminal complement pathway complex C5b-7 and anionic phospholipids, Blood 93(7)2291-2301, 1999.