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Thyroid Blocking Immunoglobulin (TBI) are antibodies against the TSHR that prevent TSH binding to the receptor causing an inhibition of TSH action and can induce hypothyroidism.

The thyrotropin receptor (TSHR) is a primary autoantigen in autoimmune thyroid disease (AITD). Autoantibodies (Ab) against the TSHR can be present either as functional thyroid-stimulating autoantibodies (TSI) causing Graves’ hyperthyroidism or as thyroid-blocking autoantibodies (TBI) causing hypothyroidism.

Measurement of these Thyroid Receptor Blocking autoantibodies can prove useful in the following areas:

  • Differential diagnosis of thyroiditis (unexplained Goiter)
  • Autoimmune Hashimoto‘s Thyroiditis (HT)
  • Graves‘ disease: post radioactive iodine treatment and/or during therapy with antithyroid drugs (some patients having both stimulating and blocking antibodies simultaneously)
  • Differential diagnosis of hypothyroidism; Autoimmune Thyroid Disease (AITD)
  • Postpartum thyroid disease, possibly PP depression
  • Autoimmune thyroid disease developing during pregnancy
  • Pediatric monitoring
  • Additional yet unknown applications

Knowing if it's TSI or TBI matters. Visit checkonemorebox.com to learn how to get the complete picture.

Features & Benefits


Product Specifications

Product Spec NameProduct Spec Data
CHO Mc4 FreshFrozenCells

Store at –70°C or lower

Control Set (Positive, Negative, Reference)

Store at –70°C or lower

Cell Attachment Solution*

Store at 2°C to 30°C

Growth Medium

Store at 2°C to 8°C

Reaction Buffer

Store at 2°C to 8°C

Luciferase Assay Reagent Set

Store at –20°C or lower

*The solution may show precipitation if stored at refrigerated temperatures. The material may be dissolved when the solution is warmed in a 35°C to 37°C water bath. It is recommended that this solution be stored at room temperature to avoid precipitation.

Ordering Information

Catalog NumberDescriptionKit Size / Case Size

Thyretain TBI Blocking Reporter BioAssay


Thyretain FreshFrozenCells and Control Set


Thyretain Media Set


Luciferase Assay Reagent Sets


Product Documentation

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