NOT AVAILABLE FOR SALE IN THE U.S.
Thyroid Blocking Immunoglobulin (TBI) are antibodies against the TSHR that prevent TSH binding to the receptor causing an inhibition of TSH action and can induce hypothyroidism.
The thyrotropin receptor (TSHR) is a primary autoantigen in autoimmune thyroid disease (AITD). Autoantibodies (Ab) against the TSHR can be present either as functional thyroid-stimulating autoantibodies (TSI) causing Graves’ hyperthyroidism or as thyroid-blocking autoantibodies (TBI) causing hypothyroidism.
Measurement of these Thyroid Receptor Blocking autoantibodies can prove useful in the following areas:
- Differential diagnosis of thyroiditis (unexplained Goiter)
- Autoimmune Hashimoto‘s Thyroiditis (HT)
- Graves‘ disease: post radioactive iodine treatment and/or during therapy with antithyroid drugs (some patients having both stimulating and blocking antibodies simultaneously)
- Differential diagnosis of hypothyroidism; Autoimmune Thyroid Disease (AITD)
- Postpartum thyroid disease, possibly PP depression
- Autoimmune thyroid disease developing during pregnancy
- Pediatric monitoring
- Additional yet unknown applications
Knowing if it's TSI or TBI matters. Visit checkonemorebox.com to learn how to get the complete picture.
Features & Benefits
| Feature | Benefit |
|---|
Product Specifications
| Product Spec Name | Product Spec Data |
|---|---|
CHO Mc4 FreshFrozenCells | Store at –70°C or lower |
Control Set (Positive, Negative, Reference) | Store at –70°C or lower |
Cell Attachment Solution* | Store at 2°C to 30°C |
Growth Medium | Store at 2°C to 8°C |
Reaction Buffer | Store at 2°C to 8°C |
Luciferase Assay Reagent Set | Store at –20°C or lower |
*The solution may show precipitation if stored at refrigerated temperatures. The material may be dissolved when the solution is warmed in a 35°C to 37°C water bath. It is recommended that this solution be stored at room temperature to avoid precipitation.
Ordering Information
| Catalog Number | Description | Kit Size / Case Size |
|---|---|---|
40-35010 | Thyretain TBI Blocking Reporter BioAssay | |
Includes: | ||
Thyretain FreshFrozenCells and Control Set | 1 | |
Thyretain Media Set | 1 | |
Luciferase Assay Reagent Sets | 10 |
