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Monoclonal Antibody to Human SC5b-9 (Neoantigen)**

** FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES

A murine monoclonal antibody to a neoantigen on the terminal complement complex

Specifications
Catalog number:   A239  
Isotype:   IgG2bk  
Protein Concentration:   > 1.0 mg/ml  
Volume/Vial:   100 µl  
Storage:   2-8°C 

Specificity

This monoclonal antibody was raised against purified human C9. This antibody has been shown to bind to a neoantigen expressed on SC5b-9, TCC, MAC, poly- C9 and on denatured immobilized C9.

Applications

Quidel's TCC monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, and Immunohistochemistry. Please contact Quidel technical assistance for details on these or other applications.

References
  • Stoltzner, S., Lemerre, C. et al., Temporal accrual of complement proteins in Amyloid plaques in patients with down's syndrome with Alzheimer's Disease, Am J Path 156:489-499, 2000.
  • Rogers, J., N. Cooper, et al., Complement Activation by ß-amyloid in Alzheimer disease, PNAS 89:10016-10020, 1992.
  • Gemmell, C., A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480, 1997.
  • Depisch, R. V. Schmitt et al., Fluid phase generation of terminal complement complex as a novel index of bio-incompatibility, Kidney Int'l, 37, 696-627 1990.
  • S. Merri, Junnikala, S., Exceptional Resistance of Human H2 Gioblastoma Cells to Complement Mediated Killing by Expression and Utilization of Factor H and Factor H Like Protein 1, J Immunol 164:11 6075-6081, 2000.
  • Ann Wright, S Morrison., Effect of C2 Associated Carbohydrate structure of Ig Effector function: studies with chimeric mouse human IgG1 Antibodies in glycosylation mutants of chinese hamster ovary cells, J. Immunol 160:3393-3402, 1998.
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